DEPRESSION & TREATMENT-RESISTANT DEPRESSION
Depression can affect motivation, energy, concentration, sleep, appetite, relationships, work, interests, and the ability to imagine a meaningful future.
Treatment-resistant depression generally refers to major depressive disorder that has not responded adequately to appropriate antidepressant treatment, commonly after inadequate response to two or more adequate antidepressant trials. But counting medications tells only part of the story.
Sometimes the illness is genuinely resistant to treatment. Sometimes the treatment strategy needs reconsideration.
Treatment options may include psychiatric evaluation and ongoing treatment, TMS, accelerated TMS, Spravato, IV ketamine, or selected combined strategies.
The treatment can be selected for the patient rather than the patient selected for the treatment.
What happens after improvement also matters. The objective is not simply to achieve response. It is to build a durable recovery.
